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	At SwRI, experienced chemists perform multistep synthesis of target compounds using a large variety of synthesis techniques and expertise.

Lead optimization is the process by which the chemical structure of a viable drug lead is modified in an iterative way to generate more active and/or more selective compounds.

Southwest Research Institute (SwRI) pharmaceutical industry-trained scientists offer their wide-ranging drug discovery experiences to assist clients' lead optimization needs. SwRI regularly uses an Accelrys Modeling system with a new Discovery Studio^® to carry out structure-based compound design and QSAR studies. Syntheses of a wide variety of structural types have been completed in the Synthesis and Process Chemistry Section, meeting clients' new materials needs.

For more information about our medicinal chemistry/lead optimization capabilities, or how you can contract with SwRI, please contact Stanton McHardy, Ph.D., at smchardy@swri.org or (210) 522-2669.

synchemistry.swri.org

| Microencapsulation and Nanomaterials Department | Chemistry & Chemical Engineering Division | SwRI Home |

Southwest Research Institute^® (SwRI^®), headquartered in San Antonio, Texas, is a multidisciplinary, independent, nonprofit, applied engineering and physical sciences research and development organization with 11 technical divisions.

February 06, 2012